Evo Devo

Evolutionary development - at the biological interface between genetic regulatory mechanisms and biological evolution.

homeodomain

Many genes in homeotic gene clusters contain a common sequence. The recurring motif is to be a sequence called the homeobox. The homeobox encodes a 60 residue protein homeodomain, which has a high content of basic residues. Proteins containing the homeodomain are localized in the nucleus and bind to specific DNA sequences. The homeodomain contains the helix-turn-helix motif, which is present in prokaryotic DNA-binding proteins such as Cro and lambda repressor.

[] 3D image of transcription factor homeodomain - helix-turn-helix [] image gene regulating protein 3Cro [] image DNA binding protein Homeodomain protein segment bound to DNA []

The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif, and is widely distributed in eukaryotes, being found in many chromatin regulatory factors [3].[s]

Homeotic : Homeotic genes affect embryo development by specifying the character of a body segment. Homeotic mutations produce morphologic changes in body shape (bauplan) and can be an effective means for evolutionary change because affected organisms remain reproductively viable. Homeotic mutations cause one member of a repetitive series to assume the identity of another member, for example, the transformation of sepals into petals.

[] 3D image of transcription factor homeodomain - helix-turn-helix [] image gene regulating protein 3Cro [] image DNA binding protein Homeodomain protein segment bound to DNA []

cell cycledifferentiation & embryogenesishomeobox geneshomeodomainmolecular switchesregulationcell signalingWnt signaling ~ transcription factors ~
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